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Welcome to the Empowered Patient Podcast with Karen Jagoda.  This show is a window into the latest innovations in digital health and the changing dynamic between doctors and patients.

Topics on the show include

  • the emergence of precision medicine and breakthroughs in genomics
  • advances in biopharmaceuticals
  • age-related diseases and aging in place
  • using big data from wearables and sensors
  • transparency in the medical marketplace
  • challenges for connected health entrepreneurs

The audience includes researchers, medical professionals, patient advocates, entrepreneurs, patients, caregivers, solution providers, students, journalists, and investors.

Apr 2, 2024

Cynthia Pussinen, CEO of Sernova, describes their innovative cell therapy platform, the Cell Pouch System, which can deliver functional cures for chronic diseases using therapeutic cells, tissues, proteins, and other molecules. This implantable device is made of mesh that allows for vascularization, forming a pseudo-organ that can function in the body and fulfill unmet needs. The current focus is on type one diabetes, where the Cell Pouch has shown promising results, allowing patients to become insulin-independent. Other potential applications include treating hypothyroidism and hemophilia A.  

Cynthia explains, "The Cell Pouch is a very flexible implantable device. It's made of two polypropylene mesh sheets, and in those mesh sheets, it has perfectly sized pores. So, the Cell Pouch is a couple of millimeters thick and about the size of a credit card."  

"We take the Cell Pouch and, place it in the abdominal region of the patient and let it sit for a couple of weeks. And that is to allow vascularization. So vessels and tissues grow through those pores I mentioned a moment ago of the Cell Pouch. It creates a very healthy environment for us to put those therapeutic cells or tissues or blood factors, hormones, or proteins into that Cell Pouch a couple of weeks later after that full vascularization has happened. If we put the cells in without the vascularization happening first, the cells would die."  

"After we place those therapeutic cells into the Cell Pouch, the cells in the Cell Pouch essentially form a pseudo-organ of sorts. They begin to function, fulfilling what the body was not capable of previously performing. And so in the case of our type one diabetes study, what happens is, after the Cell Pouch and cells are implanted into the patient's body, we then begin to titrate them off of insulin over the course of a couple of weeks. Then the body with the Cell Pouch and cells goes on to essentially form that pseudo-organ of sorts. We have patients now who have been insulin-independent for a number of years."

#Sernova #FunctionalCure #TypeOneDiabetes #CellTherapy #ChronicDiseases #PrecisionMedicine #Medtech

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