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Welcome to the Empowered Patient Podcast with Karen Jagoda.  This show is a window into the latest innovations in digital health and the changing dynamic between doctors and patients.

Topics on the show include

  • the emergence of precision medicine and breakthroughs in genomics
  • advances in biopharmaceuticals
  • age-related diseases and aging in place
  • using big data from wearables and sensors
  • transparency in the medical marketplace
  • challenges for connected health entrepreneurs

The audience includes researchers, medical professionals, patient advocates, entrepreneurs, patients, caregivers, solution providers, students, journalists, and investors.

Nov 17, 2021

Dr. Paul Peter Tak is the President and CEO of Candel Therapeutics which is focused on educating the immune system to recognize and kill tumor cells in patients with a solid tumor. Candel is developing immunotherapies using engineered oncolytic viruses for prostate cancer, brain cancer, lung cancer, pancreatic cancer, and eye cancer.

Paul Peter explains, "Viruses probably got a bad reputation during the pandemic, but you can actually use them to do something beneficial to a patient, and that's what we are doing. So, using molecular engineering, we change the viruses in such a way that they infect the tumor cells and that they induce cell death. They kill the tumor cells in a way that activates the patient's own immune system, which is basically a very natural way to fight cancer."

"So, at the same time, we change the so-called tumor microenvironment from a cold tumor, a tumor that is not very active in terms of immune activity, into a hot tumor where we activate a whole variety of immune cells. And that's an optimal way to immunize the patient against the patient's own variety of so-called cancer neoantigens, the molecules that are being recognized by the patient's immune system."

#CandelTherapeutics #Oncology #OncolyticVirus #Immunotherapy #LungCancer #ProstateCancer #BrainCancer #Glioma #PancreaticCancer #EyeCancer #Cancer

Download the transcript here

Candel Therapeutics