Preview Mode Links will not work in preview mode


Welcome to the Empowered Patient Podcast with Karen Jagoda.  This show is a window into the latest innovations in applying generative AI, novel therapeutics and vaccines, and the changing dynamics in the medical and healthcare environment. One focus is on how providers, pharmaceutical companies, and payers are empowering patients.  In addition, conversations are often about how providers, care facilities, pharmaceutical companies, and payers are being empowered by technology to improve patient outcomes and reduce friction across the healthcare landscape.

Popular Topics

  • Virtual and digital health
  • Use of AI, ML, and LLM in healthcare and drug discovery, development, trials
  • Value-based healthcare 
  • Precision and stratified medicine
  • Integration of digital technology into existing workflow and procedures 
  • Next-generation immuno, cell, and gene therapies
  • Vaccines
  • Biomarkers, sequencing, and imaging
  • Rare diseases
  • MedTech and medical devices
  • Clinical trials
  • Addressing Social Determinants of Health
  • Treating chronic conditions like obesity and pain
  • Clinician and staff burnout

The audience includes life science leaders, researchers, medical professionals, patient advocates, digital health entrepreneurs, patients, caregivers, healthcare solution providers, students, journalists, and investors. 


Check out our new EmpoweredPatient.Solutions site where you can quickly search all of the Empowered Patient Podcast interviews by any word or phrase to identify useful resources, potential partners, and insights about the life sciences landscape.

Empowered Patient Solutions

Nov 2, 2022

Dr. Peter Traber is the Chief Medical officer at Selecta Biosciences, which is enabling and increasing the effectiveness of gene therapy by inhibiting the body's immune response. Their drug platform ImmTOR is a nano-encapsulated immunomodulatory drug that causes the immune system to be tolerant of antigens and inhibits the immune response. This approach may overcome an important hurdle in gene therapy and biologic therapy by allowing repeated dosing.

Peter explains, "Our immune response is very robust, and it's hard to get around it. So in order to make these therapies, either proteins or gene therapy, more effective and safer, we are tolerizing the individual to those therapies with this platform."

"So I'll give you an example from our phase three program in chronic refractory gout. We're using an enzyme to treat refractory gout, which decreases the uric acid, but it's a yeast-derived enzyme. It's an enzyme that humans don't have, and therefore it's highly immunogenic. If you give it to a human, it's only effective with one dose. In fact, by 30 days, it's not effective anymore. In contrast, when we give it with ImmTOR, we're able to give the drug monthly for 12 months. So the ImmTOR reduces the immune effect of the drug but allows it to be active and be used over the course of an entire year."

"We are collaborating with some groups on transplantation approaches. And certainly, inducing immune tolerance in that situation could be very important. And, of course, beyond that, we're also working in autoimmune diseases where the body turns against itself—so-called breaking of self-tolerance. Our program is also working on reestablishing self-tolerance in autoimmune diseases. There's a very long list of autoimmune diseases in the liver and joints and elsewhere that could be very important in this regard."

@SelectaBio #MMA #GeneTherapy #ImmuneTolerance #ImmuneSystem #AutoimmuneDiseases #Transplanation

Listen to the podcast here