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Welcome to the Empowered Patient Podcast with Karen Jagoda.  This show is a window into the latest innovations in applying generative AI, novel therapeutics and vaccines, and the changing dynamics in the medical and healthcare environment. One focus is on how providers, pharmaceutical companies, and payers are empowering patients.  In addition, conversations are often about how providers, care facilities, pharmaceutical companies, and payers are being empowered by technology to improve patient outcomes and reduce friction across the healthcare landscape.

Popular Topics

  • Virtual and digital health
  • Use of AI, ML, and LLM in healthcare and drug discovery, development, trials
  • Value-based healthcare 
  • Precision and stratified medicine
  • Integration of digital technology into existing workflow and procedures 
  • Next-generation immuno, cell, and gene therapies
  • Vaccines
  • Biomarkers, sequencing, and imaging
  • Rare diseases
  • MedTech and medical devices
  • Clinical trials
  • Addressing Social Determinants of Health
  • Treating chronic conditions like obesity and pain
  • Clinician and staff burnout

The audience includes life science leaders, researchers, medical professionals, patient advocates, digital health entrepreneurs, patients, caregivers, healthcare solution providers, students, journalists, and investors. 

 

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Empowered Patient Solutions

Sep 8, 2021

Craig Parker is the Chief Executive Officer at Surrozen. Their research in the Wnt pathway and proteins identified these are critical to maintaining tissues in our body and are found in tissues as diverse as the lung, intestine, liver, sensory hair cells, and the eye. The company is first targeting a patient population with a severe alcoholic injury to the liver who are not eligible for transplant but would benefit from regeneration in their liver.

Craig explains, "It really starts with a signal outside the cell that gets transmitted inside the cell by this Wnt signaling pathway, which in turn activates a number of genes that are responsible for these processes, like tissue repair or embryonic development, or renewal of stem cells."

"The Wnt proteins actually don't dissolve very well in the circulation, and they really only act within a few cells distance from where they're produced. What made this pathway very difficult to try to modulate for therapeutic use is that these proteins, you can't just copy one of these proteins and inject it and have it activate this path in a distanced cell. These proteins are quite unique in the way they only work one or two cells away from where they're produced."

#Surrozen #wntpathway #wntproteins

Surrozen.com

Download the transcript here

Surrozen