Preview Mode Links will not work in preview mode

 

Welcome to the Empowered Patient Podcast with Karen Jagoda.  This show is a window into the latest innovations in digital health and the changing dynamic between doctors and patients.

Topics on the show include

  • the emergence of precision medicine and breakthroughs in genomics
  • advances in biopharmaceuticals
  • age-related diseases and aging in place
  • using big data from wearables and sensors
  • transparency in the medical marketplace
  • challenges for connected health entrepreneurs

The audience includes researchers, medical professionals, patient advocates, entrepreneurs, patients, caregivers, solution providers, students, journalists, and investors.

May 17, 2023

Matt D'Onofrio, Co-Founder, President, and Chief Operating Officer at Evoke Pharma, is developing a treatment to help patients with diabetic gastroparesis.  This little-known disease is thought to be due to damage to the vagus nerve, interrupting the communication between the brain and gut, stopping the stomach from functioning normally. Current treatments are a pill required to move through the stomach.  Evoke has developed a nasal spray to treat the condition that bypasses the stomach and provides predictable relief.

Matt explains, "We developed a product called GIMOTI, or nasal metoclopramide. The interest behind doing so is to completely bypass the stomach to get a dose on board for patients. The unpredictable nature of the stomach makes dosing with pills very unpredictable. We know that a number of patients who take oral treatments don't find efficacy. We believe that's, in part, because of the stomach's problems itself."

"By developing the nasal format, or GIMOTI, we are able to avoid that unpredictable issue and get the product on board directly by spraying it into the nose and getting absorption straight through the thin membrane in your nostrils, getting the product into the bloodstream from there. We found that this is very helpful for patients who do have issues with any absorption problems. We also found it helpful for patients who are nauseated and vomiting because you can't vomit up a nasal spray. There have been a number of different things we found as the product has come on the market that's been helpful for it."

#EVOK #Evoke #FightGastroparesis #DGPAwareness #DiabeticGastroparesis 

evokepharma.com

Download the transcript here

Evoke