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Welcome to the Empowered Patient Podcast with Karen Jagoda.  This show is a window into the latest innovations in digital health and the changing dynamic between doctors and patients.

Topics on the show include

  • the emergence of precision medicine and breakthroughs in genomics
  • advances in biopharmaceuticals
  • age-related diseases and aging in place
  • using big data from wearables and sensors
  • transparency in the medical marketplace
  • challenges for connected health entrepreneurs

The audience includes researchers, medical professionals, patient advocates, entrepreneurs, patients, caregivers, solution providers, students, journalists, and investors.

Mar 14, 2022

Jesús Martin-Garcia is the CEO of GeNeuro, a Swiss-based clinical stage company focused on novel approaches for treating autoimmune and neurodegenerative diseases.  While previously considered junk DNA, human endogenous retroviruses are now being seen in a new light as they represent 8% of human DNA and play a role in locking viral reproduction.

Jesús explains, "Our mission is really to focus on and to defeat neurodegenerative diseases. We have an original approach, and we believe because we are based on leveraging the biology of human endogenous retroviruses, which are the traces that are left in our DNA by the virus contaminations that affected our ancestors. We believe they play a major role in neurodegenerative diseases, such as multiple sclerosis, ALS, and now recent data has shown, long-COVID."

"Yes, that was frankly a surprise for us. It was a discovery led by some academic groups in the US and Europe that showed that SARS-CoV-2, remember I told you at the beginning, this interaction between exogenous viruses in our cells, and the fact that some of them were able to de-repress pathogenic proteins. SARS-CoV-2 was shown to be able to de-repress W-ENV, which is basically the same protein that we see in the brain of MS patients. But this time, it was really, I would say a more diverse de-repression - a stronger expression in lymphocytes in the blood, on endothelial cells of the brain, the heart, and the lung, and also all the way up to microglia, the brain, in some patients that had died from COVID."

@GeneuroO #Geneuro #Temelimab #HERVs #LongCOVID #ALS #MS #MultipleSclerosis #NIH #Retroviruses

Download the transcript here