Thin Film Freezing Technology Transforms Drugs into Dry Powder Formulations Improving Efficacy with Glenn Mattes TFF Pharmaceuticals TRANSCRIPT
Download PDFAug 3, 2021
Glenn Mattes is the CEO of TFF Pharmaceuticals, with a hybrid business model developing an internal portfolio of products and also working with external partners to apply thin film freezing technology. The first compounds are voriconazole, an antifungal being developed for treating invasive pulmonary aspergillosis, and tacrolimus, for lung transplant patients. Other compounds are targeting COVID-19.
Glenn says, "So our thin film freezing technology has the ability to transform pharmaceutical products, mostly solid pharmaceutical products, into dry powder formulations. One characteristic that is common to most pharmaceutical compounds is that they're rather poorly water absorbed. So when they are made into a drug, the ability to get enough product into the bloodstream or the plasma means you have to dose the compound at a pretty high level, and you butt up against sort of the adverse events profile."
"So, by using thin film freezing, you ultimately can lead to a lower dose of the drug being administered directly to the lung. Therefore you have the opportunity to improve on the efficacy and safety profile of the product that you're working on."
$TFFP #ThinFilmFreezing #InhalableTherapies #Voriconazole #Tacrolimus #COVID19
