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Welcome to the Empowered Patient Podcast with Karen Jagoda.  This show offers a glimpse into the latest innovations in applying generative AI, novel therapeutics and vaccines, and the evolving dynamics in the medical and healthcare landscape. One focus is on how providers, pharmaceutical companies, and payers are empowering patients.  In addition, conversations often focus on how technology is empowering providers, care facilities, pharmaceutical companies, and payers to improve patient outcomes and reduce friction across the healthcare landscape.  Popular Topics Include: Virtual and digital health Use of AI, ML, and robots for clinical and administrative purposes  Value-based healthcare  Precision and stratified medicine Next-generation immuno, cell, and gene therapies Vaccines for infectious diseases and oncology Biomarkers and diagnostics Rare diseases MedTech and medical devices Clinical trials  Population health Chronic conditions l Clinician and staff burnout Smart hospitals The audience includes life science leaders, researchers, medical professionals, patient advocates, digital health entrepreneurs, patients, caregivers, healthcare solution providers, students, journalists, and investors.
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  2. Using mRNA Vaccines to Effectively and Safely Target Infectious Disease and Cancer with Dr. Thomas VanCott and Dr. Romain Micol Combined Therapeutics TRANSCRIPT

Using mRNA Vaccines to Effectively and Safely Target Infectious Disease and Cancer with Dr. Thomas VanCott and Dr. Romain Micol Combined Therapeutics TRANSCRIPT

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Jun 8, 2023

Dr. Romain Micol, CEO, and Dr. Tom VanCott, Chief Scientific Officer, at Combined Therapeutics, are excited about the opportunities to design mRNA vaccines that target specific tissue cells to restrict protein expression and have stronger potency in the fight against infectious disease and cancer. They have designed their vaccine platform to keep the vaccine antigen expression at the injection site, protecting the liver, kidney, and heart. 

Romain explains, "So mRNA vaccines are highly effective both for infectious diseases and, more recently, to treat cancer. It's an ideal technology that is relatively easy to make and to manufacture. It could be very rapid and can get expression in vivo where protein would be folded properly. We can currently use the mRNA vaccine to deliver multiple materials to prevent infectious diseases and also cure cancer."

"The main challenge we see at Combined Therapeutics, both for vaccines for infectious disease and for cancer treatment, is in their biodistribution and potency. Our platform at Combined Therapeutics is a proprietary technology that enables us to focus protein expression in specific tissue cells and prevent off-target expression in selected cell tissue. At the moment, our R&D program covers both oncology and infectious disease."

Thomas elaborates, "What we've done here at Combined Therapeutics is we're taking advantage of something called micro RNAs. Now, what are micro RNAs? A lot of people don't know about them, but they're really just small RNA molecules that are naturally present throughout the body. They're actually fairly small molecules. They're about 22 nucleotides in size."

"But what's really important is that they're distributed differentially throughout the body. So, if you look at the lungs or the heart or the muscles, you'll see a different array of micro RNAs that are expressed in each one of those tissues, and that is exactly what we take advantage of. What we do in our mRNA is engineer into it what we call these blockers. And what's a blocker? A blocker is really a binding site for the micro RNA."

@Combined_tx #CombinedTherapeutics #mRNA #Vaccines #Cancer #Oncology #InfectiousDisease 

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Combined Therapeutics