Preview Mode Links will not work in preview mode


Welcome to the Empowered Patient Podcast with Karen Jagoda.  This show is a window into the latest innovations in digital health and the changing dynamic between doctors and patients.

Topics on the show include

  • the emergence of precision medicine and breakthroughs in genomics
  • advances in biopharmaceuticals
  • age-related diseases and aging in place
  • using big data from wearables and sensors
  • transparency in the medical marketplace
  • challenges for connected health entrepreneurs

The audience includes researchers, medical professionals, patient advocates, entrepreneurs, patients, caregivers, solution providers, students, journalists, and investors.

Dec 15, 2021

Dr. Aharona Shuali is the Vice President of Medical Affairs at Nucleix developing a liquid biopsy to detect cancer. It can be a blood test or a urine test that looks at DNA, but it doesn't look at DNA as mutations. Rather, it's looking to detect changes in methylation which are small molecules that are sitting on the DNA and have shown to be much more important than mutations in the early detection of cancer.

Aharona explains, "What we do is a unique approach that is actually using enzymes. We have a very good signal-to-noise ratio. So I'll just talk a little bit about the standard. It is usually bisulfite, and bisulfite is a chemical that is very harsh. So it usually degrades, it ruins up to 90% of the DNA, and then it also introduces a lot of noise. So when you find the low amount of DNA in the blood that is coming from the tumor, if you treat it with bisulfite, you actually are going to destroy most of it. Then what is remaining is going to be very hard to tell if this is a real signal or it's actually noise."

"However, our platform is using a proprietary enzymatic-based approach, which actually does not destroy the DNA at all and has very low noise. So we believe that this approach can tell you, even with very minute amounts of DNA floating in the blood coming from the tumor, we'll be able to detect the signal from the tumor itself."

@nucleix2 #LungCancer #BladderCancer #LungEpiCheck #SanDiego

Download the transcript hereNucleix