May 10, 2023
Steve Glover, Co-founder and CEO of ZyVersa Therapeutics, focuses on rare kidney diseases and diseases with an inflammation component. Inflammasomes, the first response in the innate immune system, create an inflammation cascade. The ZyVersa approach targets multiple inflammasomes to address diseases caused by the malfunction of this response.
Steve explains, "Inflammation drives a lot of different diseases. And as we get into this a little bit more today, it's everything from kidney disease such as rare diseases such as FSGS and Alport syndrome and diabetic kidney disease all have an inflammation component. And in addition to that, when you look at diseases like Alzheimer's or MS, or Parkinson's, they're inflammation driven as well. So there is a connection between the two disease classes."
"I've been in the industry a long time, and every so often the industry finds a new interesting discovery, and inflammasomes are clearly one of those new discoveries. In fact, one of the things I talk about quite a bit is that ten years ago, there were about two or so publications that were available on inflammasomes. Now there are over 20,000 publications available on inflammasomes. And this whole concept of inflammation driving certain diseases has become an area of an immense amount of research and development of products that can inhibit the inflammation you don't want in the human body."
"When inflammasomes go into overdrive and are left uninhibited, they can cause a lot of damage to organs and cells in the body. And so, for example, they drive a lot of different diseases, everything from cancers to diseases such as Parkinson's and Alzheimer's disease, and a whole host of CNS diseases, as well as non-CNS diseases, that are driven by this inflammasome activation. So it's really important to find a way to inhibit those cytokines by inhibiting the inflammasome."
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